Resveratrol Ameliorates the Oxidative Damage Induced by Arsenic Trioxide in the Feline Lung
نویسندگان
چکیده
منابع مشابه
Oxidative stress induced by the chemotherapeutic agent arsenic trioxide
Arsenic compounds have been used for medicinal purposes throughout history. Arsenic trioxide (As2O3) achieved dramatic remissions in patients with acute promyelocytic leukaemia. Unfortunately, the clinical usefulness of As2O3 has been limited by its toxicity. The present study was designed to investigate the toxic effects of As2O3 at its clinical concentrations. Experimental rats were administe...
متن کاملThe Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity
Arsenic trioxide (As2O3) shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Unfortunately, limiting the application of this effective agent to APL patients is severe cardiotoxicity. Resveratrol, the natural food-derived polyphenolic compound, is well known for its antioxidant properties and protects the cardiovascular system. But the potential role of res...
متن کاملAminoguanidine ameliorates radiation-induced oxidative lung damage in rats.
PURPOSE To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats. METHODS To evaluate the biological damage of radiation on rat lung tissue, lipid peroxidation products were measured using biochemical parameters. Thirty Wistar albino rats were divided into three subgroups: control (C) , irradiation alone (RT), and RT + AG combined. Af...
متن کاملResveratrol Reduces Oxidative Stress and Improves Arsenic Efflux in Rats Exposed To Arsenic Trioxide
Received: Revised: Accepted: May 29, 2013 September 15, 2013 September 18, 2013 The effects of resveratrol on arsenic trioxide-induced oxidative stress and arsenic efflux in spleen were determined in Wistar rats exposed to arsenic trioxide (As2O3). Wistar rats were segregated into four groups: control (0.9% normal saline), As2O3treated (2 mg/kg for 7 days, i.p.), resveratrol+As2O3-treated, resv...
متن کاملEvaluation of Arsenic Trioxide Potential for Lung Cancer Treatment: Assessment of Apoptotic Mechanisms and Oxidative Damage.
BACKGROUND Lung cancer is one of the most lethal and common cancers in the world, causing up to 3 million deaths annually. The chemotherapeutic drugs that have been used in treating lung cancer include cisplatin-pemetrexed, cisplastin-gencitabinoe, carboplatin-paclitaxel and crizotinib. Arsenic trioxide (ATO) has been used in the treatment of acute promyelocytic leukemia. However, its effects o...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2013
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.13-0004